The Abulkasim Madrasah (named after Sheikh Abulkasimkhan Ishana) is located between two modern buildings—the Palace of Friendship of Peoples and the Oliy Majlis building—and blends harmoniously with them with its traditional, ancient lines.

The madrasah was built in the mid-19th century on the site of a 16th-century architectural complex.

The madrasah's name is associated with Sheikh Abulkasim, who donated funds for the madrasah's construction, served as the spiritual leader of the townspeople, and is remembered as a peacemaker during the cholera riots of 1892.

Such prominent figures as Abdulla Qadiri, the founder of the Uzbek novel school; Munavvar Kary Abdurashidkhanov, the founder of the first university; playwright Gulam Zafari; and professor Abdurauf Fitrat studied at the Abulkasim Madrasah.

During the famine of the 1930s, it became a refuge for 70 families from the Volga region evacuated to Tashkent, and until 1974, it was transformed into a noisy communal courtyard. The building then housed a branch of the Tashigrushka factory.

During the years of independence, the madrasah housed folk artisans. The building is listed as a state-protected historical monument and is managed by the Tashkent branch of the Oltin Meros (Golden Heritage) International Charitable Foundation. Ceramicists, woodcarvers, engravers, and miniaturists work in the students' rooms, which overlook the courtyard. Numerous visitors can interact with the artisans, observe the process of creating artistic masterpieces, and purchase their favorite crafts. Exhibitions and festivals are held in the madrassa's courtyard.

The Abulkasim Madrassa is a regular tourist attraction and is frequently visited by Tashkent residents.